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Isoallolithocholic acid
CAS No. 2276-93-9
Isoallolithocholic acid( —— )
Catalog No. M34853 CAS No. 2276-93-9
Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) is a bile acid metabolite and T-cell modulator with anti-inflammatory activity, associated with human immune homeostasis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 150 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameIsoallolithocholic acid
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NoteResearch use only, not for human use.
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Brief DescriptionIsoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) is a bile acid metabolite and T-cell modulator with anti-inflammatory activity, associated with human immune homeostasis.
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DescriptionIsoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation.
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In Vitro——
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In VivoAnimal Model:Segmented filamentous bacteria (SFB)-colonized Jax-B6 miceDosage:0.03% (w/w) Administration:In diet, 7 days Result:Was insufficient to enhance Treg percentages both at steady state and following anti-CD3 treatment alone. Significantly enhanced the Treg population in mice treated with anti-CD3 compared to control diet in combination with 0.3% (w/w) 3-oxolithocholic acid (3-oxoLCA). Reduced the number of CD45.1+ T effector cells.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2276-93-9
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Formula Weight376.57
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Molecular FormulaC24H40O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 83.33 mg/mL (221.29 mM; Ultrasonic (<60°C); H2O : < 0.1 mg/mL (insoluble)
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SMILES[H][C@@]12CC[C@H]([C@H](C)CCC(O)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@@H](O)CC[C@]12C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hang S, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019 Dec;576(7785):143-148.?
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